SELECTED PUBLICATIONS


2018


​• ​​Andersen P, Tampakakis E, Jimenez DV, Kannan S, Chelko SP, Miyamoto M, Shin HK, Saberi A, Murphy S, Sulistio E, Kwon C. (2018) Precardiac Organoids Form Two Heart Fields via Bmp/Wnt Signaling.                 Nat Commun. (in press)


​​• Saberi A, Zhu R, Liang J, Kwon C. (2018) Complete Guide RNA Design for CRISPR-Mediated Regulation of Human Long Noncoding RNA Transcription. bioRxiv. 290338 pdf


​• Gibbs BC, Shenje L, Andersen P, Miyamoto M, Kwon C. (2018) Beta 1-integrin ls a Cell-Autonomous Factor Mediating the Numb Pathway for Cardiac Progenitor Maintenance. Biochem Biophy Res Commun.

500(2):256-260 pdf


2017


• Cho GS, Dong IL, Tampakakis E, Murphy S, Andersen P, Uosaki H, Chelko S, Chakir K, Hong I, Seo K, Chen HV, Chen X, Basso C, Houser SR, Tomaselli GF, O'Rourke B, Judge DP, Kass DA*, Kwon C* (2017) Neonatal Transplantation Confers Maturation of PSC-Derived Cardiomyocytes Conducive to Modeling Cardiomyopathy. Cell Rep.  18(2):571-582  *co-senior  pdf  The Baltimore Sun  ScienceDaily


• Cho GS, Tampakakis E, Andersen P, Kwon C (2017) Using A Neonatal Rat System as A Bioincubator to Generate Adult-like Mature Cardiomyocytes from Human and Mouse Pluripotent Stem Cells. Nat Protoc. 12(10):2097-2109 pdf 

​​

2016


Oh YH, Cho GS, Li Z, Hong I, Zhu R, Kim MJ, Kim YJ, Tampakakis E, Tung L, Huganir R, Dong X, Kwon C*, Lee G*. (2016) Functional Coupling with Cardiac Muscle Promotes Maturation of hPSC-Derived Sympathetic Neurons. Cell Stem Cell. 19(1):95-106  *co-senior   pdf   ScienceDaily 


• Morita Y, Andersen P, Hotta A, Tsukahara Y, Sasagawa N, Hayashida N, Koga C, Nishikawa M, Saga Y, Evans SM, Koshiba-Takeuchi K, Nishinakamura R, Yoshida Y, Kwon C, Takeuchi JK. (2016) Sall1 Transiently Marks Undifferentiated Heart Precursors and Regulates their Fate.  J Mol Cell Cardiol.  92:158-62 (Cover)  pdf



                                                                                                    2015

Uosaki H, Cahan P, Lee DI, Wang S, Miyamoto M, Fernandez L, Kass DA, Kwon C. (2015) Transcriptional Landscape of Cardiomyocyte Maturation. Cell Rep. 13(8):1705-16  pdf  ScienceDaily

•​ Lee D, Zhu GS, Sasaki T, Jo SH, Danner T, Zhang M, Rainer P, Bedja D, Dostmann W, Takimoto E, Cho GS, Hamdani N, Holewinski R, Kirk J, Renek M, Kwon C, Margulies K, Van Eyk J, Paulus W, Kass DA. (2015) Phosphodiesterase 9A Controls Nitric-oxide Independent cGMP and Hypertrophic Heart Disease. Nature.  519(7544):472-6  pdf  ScienceDaily

Andersen P, Kwon C. (2015) Ex-Vivo Culture of Pharyngeal Arches for Heart and Muscle Progenitors and Niche.  J Vis Exp. 101:e52876​​ pdf


Kwon C, Tomaselli GF. (2015) Coins of the Realm in Atroventricular Junction Development. Circ Res.           116:386-88  pdf


                                                                                                    2014


Shenje L, Andersen P, Uosaki H, Fernandez L, Cho GS, Rainer P, Zhong W, Harvey RP, Kass DA, Kwon C. (2014) Precardiac Deletion of Numb and Numblike Reveals Renewal of Cardiac Progenitors. eLife. 3:e02164  pdf  Insight ScienceDaily   


Shenje L, Andersen P, Halushka M, Lui C, Fernandez L, Collin G, Amat-Alarcon N, Meschino M, Cutz E, Chang K, Yonescu R, Batista D, Chen Y, Chelko S, Crosson J, Scheel J, Vricella L, Craig B, Marosy B, Mohr D, Hetrick K, Romm J, Scott A, Valle D, Naggert J, Kwon C, Doheny KF, Judge DP. (2014) Mutations in Alström Protein Impair Terminal Differentiation of Cardiomyocytes. Nat Commun.  5:3416  pdf

• Cho GS, Fernandez L, Kwon C. (2014) Regenerative Medicine for the Heart: Perspectives on Stem-Cell Therapy. Antioxid Redox Signal.  21(14):2018-31  pdf


                                                                                                    2013

Cheng P, Andersen P, Hassel D, Kaynak B, Limphong P, Juergensen L, Kwon C*, Srivastava D*. (2013) Fibronectin Mediates Mesendodermal Cell Fate Decisions. Development.  140(12):2587–96  *co-senior pdf

Uosaki H, Magadum A, Seo K, Fukushima H, Takeuchi A, Nakagawa Y, Moyes KW, Narazaki G, Kuwahara K, Laflamme M, Matsuoka S, Nakatsuji N, Nakao K, Kwon C, Kass DA, Engel F, Yamashita JK. (2013) Identification of Chemicals Inducing Cardiomyocyte Proliferation in Developmental State-Specific Manner with Pluripotent Stem Cells. Circ Cardiovas Genet.  6(6):624-33  pdf

 
                                                                                                    2012

Andersen P, Uosaki H, Shenje L, Kwon C. (2012) Non-Canonical Notch Signaling: Emerging Role and Mechanism. Trends Cell Biol.  22(5):257-65  pdf

• Uosaki H, Andersen P, Shenje L, Lindegren SC, Kwon C. (2012) Direct Contact with Endoderm-like Cells Efficiently Induces Cardiac Progenitors from Mouse and Human Pluripotent Stem Cells. PLoS One.              7(10):e46413  pdf


                                                                                                    2011

Kwon C*, Cheng P, King IN, Andersen P, Shenje L, Nigam V, Srivastava D*. (2011) Notch Post-translationally Regulates β-Catenin Protein in Stem and Progenitor Cells. Nat Cell Biol. 13(10):1244-1251 *co-senior  pdf  F1000  ScienceDaily                                                

King IN, Qian L, Liang J, Huang Y, Shieh J, Kwon C, Srivastava D. (2011) A Genome-Wide Screen Reveals a Role for microRNA-1 in Modulating Cardiac Cell Polarity. Dev Cell.  20(4):951-501  pdf    ScienceDaily

Srivastava D and Kwon C. (2011) Signaling Pathways Involved in Cardiogenesis Intercellular Signaling in Development and Disease (Bradshaw RA, Dennis EA, eds.), Academic Press.  pdf

van Weerd HV, Koshiba-Takeuchi K, Kwon C, Takeuchi JK. (2011). Epigenetic Factors and Cardiac Development. Cardiovasc Res.  92(2):203-211  pdf


                                                                                        2010 & Earlier 

Kwon C*, Qian L, Cheng P, Nigam V, Arnold J and Srivastava D*. (2009) A Regulatory Pathway Involving Notch/β-Catenin/Isl1 Determines Cardiac Progenitor Cell Fate. Nat Cell Biol.  11(8):951–957  *co-corresponding  pdf
                                                                                                 
Kwon C*, Cordes KR and Srivastava D. (2008) Wnt/β-Catenin Signaling Acts at Multiple Developmental Stages to Promote Mammalian Cardiogenesis Cell Cycle.  7:3815–3818  *corresponding   pdf
                                                                                                
Kwon C, Arnold J, Hsiao E, Taketo MM, Conklin BR and Srivastava D. (2007). Canonical Wnt signaling is a positive regulator in mammalian cardiogenesis Proc Natl Acad Sci U S A.  104:10894–10899  pdf
                                                                                                 
Kwon C, Han Z, Olson EN, and Srivastava D. (2005). MicroRNA1 Influences Cardiac Development in Drosophila and Regulates Notch signaling. Proc Natl Acad Sci U S A.  102:18986–18991  pdf   In This Issue PNAS    ScienceDaily
                                                                                                   
Kwon C, Hays R, Fetting J, and Orenic TV. (2004). Opposing inputs by Hedgehog and Brinker define a stripe of hairy expression in the Drosophila leg imaginal disc. Development.  131:2681–2692  pdf

C KWON LAB
Johns Hopkins University School of Medicine
720 Rutland Ave, Ross 954/1018
Baltimore MD 21205
Phone: 410-502-2154/ Fax: 443-287-6638

Copyright © CK LABORATORY

CHULAN KWON LABORATORY