Comp Biol & Gene Editing

We are developing and applying machine-learning-based metrics to study cardiac maturation and disease mechanisms. We are also creating a new genome-editing tool to correct inherited genetic diseases. Together, these efforts aim to advance both cardiac biology and therapeutic innovation.

CMAC: A Deep Learning Framework for Absolute Cardiomyocyte Transcription Age Estimation

Quansah KK, Zureick N, Chen E, Murphy S, Anderson E, Kwon E, Suh D, Stein-O'Brien G, Cahan P, Kwon C

bioRxiv 2026

SEME Enables Programmable Transcript Reconstruction through Synthetic Microexon Incorporation

Go M, Oh J, Moon S, Chen E, Kim B, Suh D, Kim S, Kwon C*, Lee SH*

bioRxiv 2026

Machine Learning in Nonischemic Cardiomyopathy: Phenotyping, Mechanism Discovery, and Clinical Applications

Quansah KK, Anderson E, Kwon E, Kwon C

Cardiology Review 2026

Machine Learning Models Enhance Detection of Arrhythmogenic Right Ventricular Cardiomyopathy

Quansah KK, Murphy SA, Kwon E, Anderson E, Tichnell C, Murray B, Gaines S, Gasperetti A, James CA, Calkins H, Carrick RT, Kwon C.

Machine Learning: Health 2026

Establishment of a Homozygous LMNA Knock-out Human Induced Pluripotent Stem Cell Line using CRISPR/Cas9 System

Park SH, Suh D, Kim H, Lee RR, Coscarella IL, Oh J, Kim S, Kim HP, Kwon C, Lee CJ, Park SW, Lee S

Stem Cell Research 2025

Platform-Agnostic CellNet Enables Cross-Study Analysis of Cell Fate Engineering Protocols

Lo EKW, Velazquez JJ, Peng D, Kwon C, Ebrahimkhani MR, Cahan P.

Stem Cell Reports 2023

Trajectory Reconstruction Identifies Dysregulation of Perinatal Maturation Programs in Pluripotent Stem Cell-Derived Cardiomyocytes

Kannan S, Miyamoto M, Zhu R, Lynott M, Guo J, Chen EZ, Colas AR, Lin BL, Kwon C

Cell Reports 2023

Cross-Organ Transcriptomic Comparison Reveals Universal Factors during Maturation

Kambhampati S, Murphy S, Uosaki H, Kwon C

Journal of Computational Biology 2022

Transcriptomic Entropy Benchmarks Stem Cell-Derived Cardiomyocyte Maturation against Endogenous Tissue at Single Cell Level

Kannan S, Farid M, Lin BL, Miyamoto M, Kwon C

PLoS Computational Biology 2021

PGC1/PPAR Drive Cardiomyocyte Maturation at Single Cell Level via YAP1 and SF3B2

Murphy SA, Miyamoto M, Kervadec A, Kannan S, Tampakakis E, Kambhampati S, Lin BL, Paek S, Andersen P, Lee DI, Zhu R, An SS, Kass DA, Uosaki H, Colas AR, Kwon C

Nature Communications 2021

Complete Guide RNA Design for CRISPR-Mediated Regulation of Human Long Noncoding RNA Transcription

Saberi A, Zhu R, Kwon C

bioRxiv 2018

Transcriptional Landscape of Cardiomyocyte Maturation

Uosaki H, Cahan P, Lee DI, Wang S, Miyamoto M, Fernandez L, Kass DA, Kwon C

Cell Reports 2015

Comp Biol & Gene Editing ​

Comp Biol & Gene Editing