Papers in bold were led by members of the Kwon lab.

2021

2020

Capturing Cardiogenesis in Gastruloids

Rossi G, Broguiere N, Miyamoto M, Boni A, Guiet R, Girgin M, Kelly RG, Kwon C, Lutolf MP

Cell Stem Cell

Pluripotent stem cells are insensitive to the cytotoxicity of TNFα and IFNγ

Chen B, Gurung C, Guo J, Kwon C, Guo YL

Reproduction

Transcriptomic entropy quantifies cardiomyocyte maturation at single cell level

Kannan S, Farid M, Lin BL, Miyamoto M, Kwon C

bioRxiv

A Novel Fluorescent Reporter System Identifies Laminin-511/521 as Potent Regulators of Cardiomyocyte Maturation

Chanthra N, Abe T, Miyamoto M, Sekiguchi K, Kwon C, Hanazono Y, Uosaki H

Scientific Reports

Proteogenomic single cell analysis of skeletal muscle myocytes

Fomchenko KM, Verma RX, Kannan S, Lin BL, Yang X, Nieuwenhuis TO, Patil AH, Fox-Talbot K, McCall MN, Kwon C, Kass DA, Rosenberg AZ, Halushka MK

bioRxiv

2019

Neurons Derived from Human Induced Pluripotent Stem Cells Integrate into Rat Brain Circuits and Maintain both Excitatory and Inhibitory Synaptic Activities

Yin X, Xu JC, Cho GS, Kwon C, Dawson TM, Dawson VL

eNeuro

In Vitro Generation of Heart Field-specific Cardiac Progenitor Cells

Tampakakis E, Miyamoto M, Kwon C

JoVE

Large particle fluorescence-activated cell sorting enables high quality single cell RNA-sequencing and functional analysis of adult cardiomyocytes

Kannan S, Miyamoto M, Lin B, Zhu R, Murphy S, Kass D, Andersen P, Kwon C

bioRxiv

Now also at Circulation Research

2018

Regulation of cardiomyocyte maturation during critical perinatal window

Kannan S, Kwon C

Journal of Physiology

Sadahiro T, Isomi M, Muraoka N, Kojima H, Haginiwa S, Kurotsu S, Tamura F, Tani H, Tohyama S, Fujita J, Miyoshi H, Kawamura Y, Goshima N, Iwasaki YW, Murano K, Saito K, Oda M, Andersen P, Kwon C, Uosaki H, Nishizono H, Fukuda K, Ieda M

Tbx6 Induces Nascent Mesoderm from Pluripotent Stem Cells and Temporally Controls Cardiac versus Somite Lineage Diversification

Cell Stem Cell

Nature Communications

Precardiac organoids form two heart fields via Bmp/Wnt signaling

Andersen P, Tampakakis E, Jimenez DV, Kannan S, Miyamoto M, Shin HK, Saberi A, Murphy S, Sulistio E, Chelko SP, Kwon C

β1-integrin is a cell-autonomous factor mediating the Numb pathway for cardiac progenitor maintenance

Gibbs BC, Shenje L, Andersen P, Miyamoto M, Kwon C

Biochemical and Biophysical Research Communications

Complete guide RNA design for CRISPR-mediated regulation of human long noncoding RNA transcription

Saberi A, Zhu R, Kwon C.

bioRxiv

2017

Use of a neonatal rat system as a bioincubator to generate adult-like mature cardiomyocytes from human and mouse pluripotent stem cells

Cho GS, Tampakakis E, Andersen P, Kwon C

Nature Protocols

Neonatal Transplantation Confers Maturation of PSC-Derived Cardiomyocytes Conducive to Modeling Cardiomyopathy

Cho GS, Lee DI, Tampakakis E, Murphy S, Andersen P, Uosaki H, Chelko S, Chakir K, Hong I, Seo K, Chen HV, Chen X, Basso C, Houser SR, Tomaselli GF, O'Rourke B, Judge DP, Kass DA, Kwon C

Cell Reports

2016

Functional Coupling with Cardiac Muscle Promotes Maturation of hPSC-Derived Sympathetic Neurons

Oh Y, Cho GS, Li Z, Hong I, Zhu R, Kim MJ, Kim YJ, Tampakakis E, Tung L, Huganir R, Dong X, Kwon C, Lee G

Cell Stem Cell

Sall1 transiently marks undifferentiated heart precursors and regulates their fate

Morita Y, Andersen P, Hotta A, Tsukahara Y, Sasagawa N, Hayashida N, Koga C, Nishikawa M, Saga Y, Evans SM, Koshiba-Takeuchi K, Nishinakamura R, Yoshida Y, Kwon C, Takeuchi JK

Journal of Molecular and Cellular Cardiology

2015

Transcriptional Landscape of Cardiomyocyte Maturation

Uosaki H, Cahan P, Lee DI, Wang S, Miyamoto M, Fernandez L, Kass DA, Kwon C

Cell Reports

Ex Vivo Culture of Pharyngeal Arches to Study Heart and Muscle Progenitors and Their Niche

Andersen P, Kwon C

Journal of Visual Experiments

Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease

Lee DI, Zhu G, Sasaki T, Cho GS, Hamdani N, Holewinski R, Jo SH, Danner T, Zhang M, Rainer PP, Bedja D, Kirk JA, Ranek MJ, Dostmann WR, Kwon C, Margulies KB, Van Eyk JE, Paulus WJ, Takimoto E, Kass DA

Nature

Circulation Research

Kwon C, Tomaselli G

Coins of the Realm in Atrioventricular Junction Development

2014

Cho GS, Fernandez L, Kwon C

Regenerative Medicine for the Heart: Perspectives on Stem-Cell Therapy

Antioxidants and Redox Signaling

Precardiac deletion of Numb and Numblike reveals renewal of cardiac progenitors

Shenje LT, Andersen P, Uosaki H, Fernandez L, Rainer PP, Cho GS, Lee DI, Zhong W, Harvey RP, Kass DA, Kwon C

eLife

Mutations in Alström protein impair terminal differentiation of cardiomyocytes.

Shenje LT, Andersen P, Halushka MK, Lui C, Fernandez L, Collin GB, Amat-Alarcon N, Meschino W, Cutz E, Chang K, Yonescu R, Batista DA, Chen Y, Chelko S, Crosson JE, Scheel J, Vricella L, Craig BD, Marosy BA, Mohr DW, Hetrick KN, Romm JM, Scott AF, Valle D, Naggert JK, Kwon C, Doheny KF, Judge DP

Nature Communications

2013

Identification of chemicals inducing cardiomyocyte proliferation in developmental stage-specific manner with pluripotent stem cells

Uosaki H, Magadum A, Seo K, Fukushima H, Takeuchi A, Nakagawa Y, Moyes KW, Narazaki G, Kuwahara K, Laflamme M, Matsuoka S, Nakatsuji N, Nakao K, Kwon C, Kass DA, Engel FB, Yamashita JK

Circulation Cardiovascular Genetics

Cheng P, Andersen P, Hassel D, Kaynak BL, Limphong P, Juergensen L, Kwon C, Srivastava D

Fibronectin mediates mesendodermal cell fate decisions

Development

2012

Direct contact with endoderm-like cells efficiently induces cardiac progenitors from mouse and human pluripotent stem cells

Uosaki H, Andersen P, Shenje LT, Fernandez L, Christiansen SL, Kwon C

PLoS Science

Non-canonical Notch signaling: emerging role and mechanism

Andersen P, Uosaki H, Shenje LT, Kwon C

Trends in Cell Biology

2011

Notch post-translationally regulates β-catenin protein in stem and progenitor cells

Kwon C, Cheng P, King IN, Andersen P, Shenje L, Nigam V, Srivastava D

Nature Cell Biology

Epigenetic factors and cardiac development

van Weerd JH, Koshiba-Takeuchi K, Kwon C, Takeuchi JK

Cardiovascular Research

A genome-wide screen reveals a role for microRNA-1 in modulating cardiac cell polarity

King IN, Qian L, Liang J, Huang Y, Shieh JT, Kwon C, Srivastava D

Developmental Cell

Pre-2010

A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate

Kwon C, Qian L, Cheng P, Nigam V, Arnold J, Srivastava D

Nature Cell Biology

Wnt/beta-catenin signaling acts at multiple developmental stages to promote mammalian cardiogenesis

Kwon C, Cordes KR, Srivastava D

Cell Cycle

Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors

Kwon C, Arnold J, Hsiao EC, Taketo MM, Conklin BR, Srivastava D

PNAS

MicroRNA1 influences cardiac differentiation in Drosophila and regulates Notch signaling

Kwon C, Han Z, Olson EN, Srivastava D

PNAS

Opposing inputs by Hedgehog and Brinker define a stripe of hairy expression in the Drosophila leg imaginal disc

Kwon C, Hays R, Fetting J, Orenic TV

Development